Depression Wiki

St. John's Wort is an dietary supplement remedy commonly used for depression. Studies have shown some effectiveness in treatment for mild to moderate depression. The active compounds in St John's Wort are unknown, but two being studied are hypericin and hyperforin.


St. John's Wort has been recorded as interacting with the following:

  • Antidepressants
  • Allergy treatment drugs
  • Cough medicine containing Dextromethorphan
  • Digoxin
  • Drugs that suppress the immune system
  • Drugs to fight HIV
  • Birth control pills
  • Reserpine (blood pressure medication)
  • Sedatives
  • Theophylline (asthma medication)
  • Migraine medication
  • Warfarin
  • Some antifungal drugs
  • Statins (medication to lower cholesterol)
  • Calcium channel blockers (to lower blood pressure)